Bringing hope to millions of Spinal Cord Injury (SCI) patients worldwide

Thousands of spinal cord injuries occur globally every year, primarily resulting from trauma caused by traffic accidents, falls and sports. In the U.S alone, over 17,000 new SCI cases are reported each year. SCI patients usually suffer irreversible damage with further tissue degeneration. SCI patients are 2 to 5 times more likely to suffer premature death, and bear tremendous healthcare costs ranging from $350,000 to $1 million in the first year alone.

Matricelf’s regenerative medicine platform brings new hope to SCI patients across the world – a future in which they will be able to live productive and independent life.

100% autologous neural implants in a matter of weeks

The process begins with a small biopsy, taken from the patient’s omentum tissue by an abdominal incision. The omental biopsy undergoes a proprietary decellularization process that results in thermo-responsive hydrogel formation, while induced pluripotent stem cells (iPSCs) are re-programmed from patient’s mature cells.

Ex-vivo differentiation of iPSCs within the thermo-responsive hydrogel leads to the generation of a functional, patient-specific neural implants that are capable of bridging injured spinal tissue.

From clinical trial success to disruptive SCI treatment

Matricelf has demonstrated promising pre-clinical results on animals with spinal cord injuries. 100% of the SC injured mice, treated with Matricelf neural implant, regained their walking ability. The unprecedented outcome paved the way for a first in human I/IIa clinical trial scheduled for 2024.

2024 Clinical Trial

Phase I/IIa clinical trial of autologous neural implant for the treatment of paralysis caused by traumatic spinal cord injury
5-10 patients
Location: Israel